Glucophage, Avandamet(metformin glycinate)
/ Metformin, Actoplus Met, Avandamet, Competact, Ebymect, Efficib, Eucreas, Fortamet, Glumetza, Icandra, Invokamet, Janumet, Jentadueto, Kazano, Komboglyze, Metformin, Metformin /, Prandimet, Qternmet, Qtrilmet, Ristfor, Segluromet, Sitagliptin / Metformin, Synjardy, Trijardy, Velmetia, Vipdomet, Vokanamet, Xigduo, Zituvimet, Zomarist (metformin glycinate) is an unknown pharmaceutical. Metformin glycinate was first approved as Glucophage on 1995-03-03. It has been approved in Europe to treat type 2 diabetes mellitus.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
Fortamet, Glumetza (generic drugs available since 2002-01-24, discontinued: Glucophage, Riomet)
CombinationsActoplus met, Invokamet, Janumet, Jentadueto, Kazano, Segluromet, Synjardy, Trijardy, Xigduo, Zituvimet (generic drugs available since 2002-01-24, discontinued: Avandamet, Glucovance, Kombiglyze, Metaglip, Prandimet, Qternmet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alogliptin benzoate
+
Metformin hydrochloride
Canagliflozin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INVOKAMET | Johnson & Johnson | N-204353 RX | 2014-08-08 | 4 products, RLD, RS |
| INVOKAMET XR | Johnson & Johnson | N-205879 RX | 2016-09-20 | 4 products, RLD, RS |
Dapagliflozin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XIGDUO XR | AstraZeneca | N-205649 RX | 2014-10-29 | 5 products, RLD, RS |
Dapagliflozin
+
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| QTERNMET XR | AstraZeneca | N-210874 DISCN | 2019-05-02 | 4 products, RLD |
Hide discontinued
Empagliflozin
+
Linagliptin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRIJARDY XR | Boehringer Ingelheim | N-212614 RX | 2020-01-27 | 4 products, RLD, RS |
Empagliflozin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYNJARDY | Boehringer Ingelheim | N-206111 RX | 2015-08-26 | 4 products, RLD, RS |
| SYNJARDY XR | Boehringer Ingelheim | N-208658 RX | 2016-12-09 | 4 products, RLD, RS |
Ertugliflozin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEGLUROMET | Merck & Co | N-209806 RX | 2017-12-19 | 4 products, RLD, RS |
Glipizide
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| METAGLIP | Bristol Myers Squibb | N-021460 DISCN | 2002-10-21 | 3 products, RLD |
Hide discontinued
Glyburide
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| GLUCOVANCE | Bristol Myers Squibb | N-021178 DISCN | 2000-07-31 | 3 products, RLD |
Hide discontinued
Linagliptin
+
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| JENTADUETO | Boehringer Ingelheim | N-201281 RX | 2012-01-30 | 3 products, RLD, RS |
| JENTADUETO XR | Boehringer Ingelheim | N-208026 RX | 2016-05-27 | 2 products, RLD, RS |
Metformin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FORTAMET | Andrx Corporation | N-021574 RX | 2004-04-27 | 1 products, RLD |
| GLUMETZA | Santarus | N-021748 RX | 2005-06-03 | 2 products, RLD, RS |
Show 5 discontinued
Metformin hydrochloride
+
Pioglitazone hydrochloride
Metformin hydrochloride
+
Repaglinide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRANDIMET | Novo Nordisk | N-022386 DISCN | 2008-06-23 | 2 products, RLD |
Hide discontinued
Metformin hydrochloride
+
Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDAMET | SB Pharmco | N-021410 DISCN | 2002-10-10 | 5 products, RLD |
Hide discontinued
Metformin hydrochloride
+
Saxagliptin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| KOMBIGLYZE XR | AstraZeneca | N-200678 DISCN | 2010-11-05 | 3 products, RLD |
Hide discontinued
Metformin hydrochloride
+
Sitagliptin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZITUVIMET | Zydus Therapeutics | N-216743 RX | 2023-11-03 | 2 products, RLD, RS |
Metformin hydrochloride
+
Sitagliptin phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| JANUMET | Merck & Co | N-022044 RX | 2007-03-30 | 2 products, RLD, RS |
| JANUMET XR | Merck & Co | N-202270 RX | 2012-02-02 | 3 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| actoplus met | New Drug Application | 2024-06-28 |
| alogliptin and metformin hydrochloride | NDA authorized generic | 2024-02-12 |
| appformin | unapproved drug other | 2011-08-08 |
| appformin-d | unapproved drug other | 2011-08-08 |
| avandamet | New Drug Application | 2012-08-30 |
| dapagliflozin and metformin hydrochloride | NDA authorized generic | 2024-06-12 |
| fortamet | New Drug Application | 2010-03-15 |
| glipizide and metformin hydrochloride | ANDA | 2018-12-11 |
| glipizide and metformin hydrochloride glipizide and metformin hydrochloride | ANDA | 2023-10-30 |
| glipizide and metformin hcl | ANDA | 2024-02-21 |
Show 40 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EMPAGLIFLOZIN / METFORMIN HYDROCHLORIDE, SYNJARDY, BOEHRINGER INGELHEIM | |||
| 2026-12-20 | PED | ||
| 2026-06-20 | NPP | ||
EMPAGLIFLOZIN / METFORMIN HYDROCHLORIDE, SYNJARDY XR, BOEHRINGER INGELHEIM | |||
| 2026-12-20 | PED | ||
| 2026-06-20 | M-296 | ||
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO, BOEHRINGER INGELHEIM | |||
| 2026-12-20 | PED | ||
| 2026-06-20 | M-295 | ||
LINAGLIPTIN / METFORMIN HYDROCHLORIDE, JENTADUETO XR, BOEHRINGER INGELHEIM | |||
| 2026-12-20 | PED | ||
| 2026-06-20 | M-295 | ||
ALOGLIPTIN BENZOATE / METFORMIN HYDROCHLORIDE, KAZANO, TAKEDA PHARMS USA | |||
| 2026-07-27 | M-300 | ||
ERTUGLIFLOZIN / METFORMIN HYDROCHLORIDE, SEGLUROMET, MSD SUB MERCK | |||
| 2024-09-17 | M-275 | ||
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET, MSD SUB MERCK | |||
| 2024-06-04 | PED | ||
| 2023-12-04 | M-187 | ||
METFORMIN HYDROCHLORIDE / SITAGLIPTIN PHOSPHATE, JANUMET XR, MSD SUB MERCK | |||
| 2024-06-04 | PED | ||
| 2023-12-04 | M-187 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Metformin Hydrochloride, Riomet Er, Sun Pharm | |||
| 9962336 | 2035-05-01 | DP | |
| Empagliflozin / Linagliptin / Metformin Hydrochloride, Trijardy Xr, Boehringer Ingelheim | |||
| 9949998 | 2034-06-11 | U-2290, U-2731 | |
| 10258637 | 2034-04-03 | U-2290, U-2731 | |
| 11090323 | 2034-04-03 | U-3192, U-3193 | |
| 11833166 | 2034-04-03 | U-3776, U-3777 | |
| 10596120 | 2032-03-07 | DP | U-2775, U-2776, U-2790, U-2792 |
| 11564886 | 2032-03-07 | DP | U-3531 |
| 10406172 | 2030-06-15 | DP | U-2733 |
| 9155705 | 2030-05-21 | DP | |
| 8551957 | 2029-10-14 | DP | U-2730 |
| 9415016 | 2029-04-02 | DP | |
| 10022379 | 2029-04-02 | U-2339, U-2732 | |
| 7579449 | 2028-08-01 | DP | |
| 7713938 | 2027-04-15 | DS, DP | |
| 8883805 | 2025-11-26 | DP | |
| 7407955 | 2025-05-02 | DS, DP | |
| Empagliflozin / Metformin Hydrochloride, Synjardy, Boehringer Ingelheim | |||
| 9949997 | 2034-05-17 | U-3532, U-3533 | |
| 11813275 | 2034-04-03 | U-3759 | |
| 10610489 | 2030-09-30 | DP | |
| Linagliptin / Metformin Hydrochloride, Jentadueto Xr, Boehringer Ingelheim | |||
| 9555001 | 2033-03-06 | DP | U-1967, U-1968 |
| 9173859 | 2027-05-04 | DP | U-1503 |
| Dapagliflozin / Metformin Hydrochloride, Xigduo Xr, Astrazeneca Ab | |||
| 9616028 | 2030-11-12 | DP | |
| 8685934 | 2030-05-26 | U-1522 | |
| 7919598 | 2029-12-16 | DP | |
| 8501698 | 2027-06-20 | DP | U-493 |
| 6515117 | 2025-10-04 | DS, DP | U-493 |
| Ertugliflozin / Metformin Hydrochloride, Segluromet, Msd Sub Merck | |||
| 9308204 | 2030-10-21 | DP | |
| 9439902 | 2030-10-21 | U-2214 | |
| 8080580 | 2030-07-13 | DS, DP | U-2214 |
| Canagliflozin / Metformin Hydrochloride, Invokamet, Janssen Pharms | |||
| 11576894 | 2030-07-06 | DP | |
| 7943582 | 2029-02-26 | DS, DP | U-493, U-2441, U-2632 |
| 8513202 | 2027-12-03 | DS, DP | U-493, U-2441, U-2632 |
| 7943788 | 2027-07-14 | DS, DP | |
| 8222219 | 2025-04-11 | U-493, U-2441, U-2632 | |
| 8785403 | 2024-07-30 | DP | |
| Linagliptin / Metformin Hydrochloride, Jentadueto, Boehringer Ingelheim | |||
| 8846695 | 2030-06-04 | U-1503 | |
| 10973827 | 2029-04-02 | DP | |
| 8673927 | 2027-05-04 | U-1503 | |
| Alogliptin Benzoate / Metformin Hydrochloride, Kazano, Takeda Pharms Usa | |||
| 8900638 | 2029-05-24 | DP | |
| 7807689 | 2028-06-27 | DS, DP | U-1337 |
| 8288539 | 2025-06-24 | DP | |
| 8173663 | 2025-03-15 | U-1338 | |
| Metformin Hydrochloride / Pioglitazone Hydrochloride, Actoplus Met, Takeda Pharms Usa | |||
| 9320714 | 2029-02-03 | DP | |
| 9101660 | 2027-01-22 | DP | |
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ATC Codes
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Clinical
Clinical Trials
2790 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 146 | 230 | 492 | 307 | 221 | 1358 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 90 | 205 | 462 | 266 | 176 | 1162 |
| Healthy volunteers/patients | — | — | — | 198 | 2 | — | 2 | 11 | 213 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 19 | 22 | 33 | 52 | 55 | 170 |
| Syndrome | D013577 | — | — | 12 | 30 | 34 | 37 | 51 | 152 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 9 | 30 | 19 | 32 | 38 | 121 |
| Insulin resistance | D007333 | HP_0000855 | — | 7 | 27 | 21 | 27 | 21 | 95 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 5 | 11 | 10 | 17 | 35 | 75 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | 4 | 6 | 18 | 12 | 25 | 61 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | 2 | 9 | 10 | 13 | 26 | 57 |
Show 172 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 9 | 2 | — | 4 | 26 |
| Adenocarcinoma | D000230 | — | — | 2 | 17 | 1 | — | 2 | 21 |
| Carcinoma | D002277 | — | C80.0 | 5 | 15 | 3 | — | 1 | 20 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 4 | 11 | 4 | — | 3 | 19 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 13 | 1 | — | 2 | 18 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 12 | 1 | — | 2 | 15 |
| Colorectal neoplasms | D015179 | — | — | 2 | 9 | 3 | — | 1 | 15 |
| Recurrence | D012008 | — | — | 2 | 4 | 2 | — | 2 | 9 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 6 | 3 | — | 2 | 9 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 8 | 6 | — | 1 | 9 |
Show 84 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 7 | 11 | — | — | 4 | 20 |
| Leukemia | D007938 | — | C95 | 3 | 4 | — | — | 3 | 10 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 4 | 5 | — | — | 1 | 9 |
| Squamous cell carcinoma | D002294 | — | — | 4 | 5 | — | — | 1 | 9 |
| Melanoma | D008545 | — | — | 3 | 7 | — | — | — | 8 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 6 | — | — | — | 8 |
| Sclerosis | D012598 | — | — | 2 | 6 | — | — | — | 7 |
| Pharmacokinetics | D010599 | — | — | 5 | 1 | — | — | 1 | 7 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | — | — | 4 | 6 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 3 | 3 | — | — | — | 6 |
Show 167 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 10 | — | — | — | 3 | 13 |
| Therapeutic equivalency | D013810 | — | — | 10 | — | — | — | 2 | 12 |
| Disease | D004194 | EFO_0000408 | R69 | 2 | — | — | — | 4 | 6 |
| Drug interactions | D004347 | — | — | 5 | — | — | — | — | 5 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | — | — | — | 3 | 4 |
| Microbiota | D064307 | — | — | 1 | — | — | — | 2 | 3 |
| Fasting | D005215 | EFO_0002756 | — | 2 | — | — | — | 1 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 2 | — | — | — | — | 2 |
| Lipid metabolism disorders | D052439 | — | — | 1 | — | — | — | 1 | 2 |
Show 44 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | — | 5 | 5 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | — | 2 | 2 |
| Disease-free survival | D018572 | EFO_0000409 | — | — | — | — | — | 2 | 2 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 2 | 2 |
| Fertilization in vitro | D005307 | — | — | — | — | — | — | 2 | 2 |
| Essential hypertension | D000075222 | — | I10 | — | — | — | — | 2 | 2 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | — | — | 2 | 2 |
| Precocious puberty | D011629 | — | E22.8 | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
Show 78 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Metformin glycinate |
| INN | metformin glycinate |
| Description | Actoplus Met, Avandamet, Competact, Ebymect, Efficib, Eucreas, Fortamet, Glucovance, Glumetza, Icandra, Invokamet, Janumet, Jentadueto, Kazano, Kombiglyze, Komboglyze, Metaglip, Prandimet, Qternmet, Qtrilmet, Ristfor, Segluromet, Synjardy, Trijardy, Velmetia, Vipdomet, Vokanamet, Xigduo, Zituvimet, Zomarist (metformin glycinate) is an unknown pharmaceutical. Metformin glycinate was first approved as Glucophage on 1995-03-03. It has been approved in Europe to treat type 2 diabetes mellitus. |
| Classification | Unknown |
| Drug class | hypoglycemics (phenformin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 121369-64-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108299 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | YEI21W005Y (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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€
£
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Janumet – Merck & Co
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 16,990 documents
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Safety
Black-box Warning
Black-box warning for: Actoplus met, Alogliptin and metformin hydrochloride, Appformin, Appformin-d, Avandamet, Dapagliflozin and metformin hydrochloride, Fortamet, Glumetza, Glyburide and metformin hydrochloride, Glyburide-metformin hydrochloride, Invokamet, Invokamet invokamet xr, Janumet, Janumet xr, Jentadueto, Jentadueto xr, Kazano, Kombiglyze, Metformin er 500 mg metformin er 750 mg, Metformin hydrochloride, Metformin hydrochloride extended-release, Metformin hydrochloride metformin hydrochloride, Metformin hydrochloride oral solution, Pioglitazole and metformin hydrochloride, Pioglitazone and metformin, Pioglitazone hydrochloride and metformin hydrochloride, Saxagliptin and metformin, Saxagliptin and metformin hydrochloride, Segluromet, Sitagliptin and metformin hydrochloride, Synjardy, Synjardy synjardy, Trijardy xr, Xigduo, Zituvimet
Adverse Events
Top Adverse Reactions
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143,228 adverse events reported
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